Source material screening, selection, collection and tracing
Working Group 1 is responsible for source material screening, selection, collection, and tracing. Together with immunology and cord blood bank experts from a number of countries, the team shall establish minimum criteria for sample quality, data and traceability in order to develop a common understanding of the (HLA) cord blood sample selection procedure.
Objectives
- Development of a common understanding of the /HLA / CB sample selection procedure
- Coordination of information seeking tracing, collection and data curation of the selected samples
WG1 Leaders
Meral Beksac
Description of Work
T1.1
Review of initiatives and literature on generation on hiPSC generation from haplo-selected CB samples (coordination and communication opportunities to understand the diversity and commonalities of approaches in different centres/countries) and organize an immunology expert meeting for CB sample selection (involving experts in HLA and non-HLA rejection and tolerance mechanisms).
T1.2
Contact (email, online conferences) CB EU banks for sample availability.
T1.3
CB bank expert meeting to establish minimal HAPLO-iPS criteria for sample quality (identifying appropriate standards for starting materials), data and traceability.
Deliverables and milestones
D1.1
Report on the common understanding of the haplo-selected CB samples selection procedure (M6).
D1.2
Report on the coordination of information seeking tracing, collection and data curation of the selected samples. (M15) M1.1: Decision on which CB samples need to be used for hiPSC generation and assess their availability.
